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Therefore, inhibiting NNMT with 5-Amino-1MQ may represent a novel approach to weight loss intervention

The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

In obese mouse models: Animals treated with 5-Amino-1MQ lost significant fat mass compared to controls Effects were most pronounced in visceral adipose tissue the metabolically dangerous fat around organs No cardiovascular toxicity or significant off-target effects were observed at research doses Body weight decreased without appetite changes, suggesting the mechanism was purely metabolic Human data is limited this is still a research compound